• Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma 

      Mohapatra, Soumya R.; Sadik, Ahmed; Tykocinski, Lars-Oliver; Dietze, Jørn; Poschet, Gernot; Heiland, Ines; Opitz, Christiane A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-04)
      Abnormal circulation in solid tumors results in hypoxia, which modulates both tumor intrinsic malignant properties as well as anti-tumor immune responses. Given the importance of hypoxia in glioblastoma (GBM) biology and particularly in shaping anti-tumor immunity, we analyzed which immunomodulatory genes are differentially regulated in response to hypoxia in GBM cells. Gene expression analyses ...